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Here he depicted Columbus defending his plans before the Council of Salamanca. It’s one of these typical history paintings with well arranged groups of persons and an illumination like on a stage.
But the real interesting thing is that Columbus is in a very similar pose like the then so popular anticlerical heroes Luther or Galileo. His clerical adversaries rely on books, Columbus instead stands alone only supported by his maps. He’s a modern man fighting against religious ignorance. And that for Powell is claiming him as a real American hero.